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Fenazine 25mg Injection
Fluphenazine Decanoate is used in the long-term management of psychotic disorders including, Schizophrenia, Mania, and Organic brain syndrome. It is not recommended for use in children and elderly patients with dementia.
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✅ Description:
- Fenazine 25mg Injection contains Fluphenazine, an antipsychotic drug.
- Used to manage chronic schizophrenia in patients requiring prolonged parenteral neuroleptic therapy.
- Schizophrenia is a serious mental disorder with symptoms like hallucinations, abnormal thoughts, delusions, and disordered behavior.
Avoid use in the following conditions:
- Severe liver disorders.
- Subcortical brain damage.
- Severely depressed states/coma.
- Prolactin-dependent tumors (e.g., breast cancer, prolactinoma).
- Parkinson's disease.
- Severe blood cell (leucopenia) or bone marrow damage.
- History of neuroleptic malignant syndrome.
Common side effects: Dyskinesia (muscle weakness), Fatigue, and Noticeable flattening.
Inform your doctor if you have:
- Slow heartbeat issues.
- Pre-existing heart damage.
- Congenital/family history of prolonged QT interval.
- Coronary heart disease.
- Conduction disturbance and arrhythmia.
- Chronic respiratory disorders or asthma.
- Liver or kidney dysfunction.
- Adrenal tumor.
- Very low or high blood pressure.
- Low potassium levels.
- History of organic brain disorders.
- Epileptic seizures.
- Depression or reduced consciousness.
- Exposure to high temperature.
- Glaucoma.
- Enlarged prostate.
- Trouble passing urine.
- Narrowing of the opening from the stomach to the duodenum.
Safety Advices
Alcohol
UNSAFE
Fenazine may cause excessive drowsiness when taken with alcohol.
Pregnancy
UNSAFE
Fenazine may be unsafe during pregnancy. While there are limited human studies, animal studies have shown harmful effects on the developing baby. A doctor will assess the benefits and potential risks before prescribing it. Consult your doctor if you are pregnant.
Breastfeeding
UNSAFE
Fenazine is probably unsafe during breastfeeding. Limited human data suggests that the drug may pass into breast milk and harm the baby. If Fenazine is administered, monitor the baby for excessive sleepiness.
Driving
CAUTION
Fenazine may decrease alertness, affect vision, or cause sleepiness and dizziness. Avoid driving if these symptoms occur. Caution is advised when operating machinery.
Kidney
CAUTION
Limited information is available on the use of Fenazine in patients with kidney disease. Consult your doctor for guidance.
Liver
CAUTION
Fenazine should be used with caution in patients with liver disease. Dose adjustment may be necessary. Consult your doctor.
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✔️ Uses of Fenazine 25mg Injection
- Psychotic Disorders
- Schizophrenia
- Mania
- Organic brain syndrome
✔️ How does Fenazine 25mg Injection work?
It works by blocking the action of dopamine, a chemical messenger in the brain that affects thoughts and mood.
✔️ How to Administer Fenazine 25mg Injection?
Fenazine 25mg Injection will be given to you only by a doctor or a nurse into the muscle (intramuscularly) or under the skin (subcutaneously). Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
✔️ Side Effects of Fenazine 25mg Injection
- Common: Anticholinergic effects, sedation, weight gain, erectile dysfunction, oligomenorrhea or amenorrhea.
- Less Common: Orthostatic hypotension (after IM injection), tachycardia, agitation, anxiety, cerebral edema, depression, dizziness, euphoria, headache, poikilothermia, restlessness, weakness, anorexia, constipation, dyspepsia, ileus, lens opacities (with prolonged use).
- Uncommon: ECG changes, photosensitivity, pruritus, diarrhea, blood dyscrasia, galactorrhea, ejaculatory disorder.
- Rare: Seizure, priapism, cholestatic jaundice.
✔️ Quick Suggestions:
- Use with caution in pregnant women.
- Not recommended during breastfeeding.
- Not recommended for children below 12 years.
- Use with caution in elderly patients, especially those with dementia-related psychosis, due to an increased risk of dementia.
✔️ Indications:
Fluphenazine is used in the treatment of psychotic symptoms such as hallucinations, delusions, and agitation.
✔️ Pharmacology
- Fluphenazine blocks postsynaptic dopamine D1 and D2 receptors in the mesolimbic system.
- Decreases the release of hypothalamic and hypophyseal hormones.
- Reduces aggressiveness with the disappearance of hallucinations and delusions.
✔️ Dosage & Administration of Fenazine 25mg Injection
Adult Dose:
- Indication: Psychoses; Mania; Schizophrenia
- Formulation: Intramuscular (as decanoate)
- Initial Dose: 12.5 mg
- Adjustment: Based on individual response
- Maintenance Dose: 12.5-100 mg at intervals of 2-6 weeks
- Increment for Doses >50 mg: Incremental steps of 12.5 mg, made slowly
- Elderly: 6.25 mg adjusted according to response
- Hepatic Impairment: Use with caution; monitor
Child Dose:
- Safety and Efficacy: Not established
Renal Dose:
- Renal Impairment: Use with caution; monitor
✔️ Interaction
- Reduced Antihypertensive Effects: Reduces antihypertensive effects of guanethidine, methyldopa, and clonidine.
- Lithium Toxicity: Lithium toxicity.
- Reduced Bioavailability: Reduced bioavailability with antacids.
- Increased Risk of Arrhythmia: Increased risk of arrhythmia when used with drugs that prolong QT interval.
- Electrolyte Disturbance: This may cause electrolyte disturbance when used with diuretics.
- Potentially Fatal: Additive CNS depressant effects with alcohol, barbiturates, hypnotics, sedatives, opiates, and antihistamines.
✔️ Contraindications
- Hypersensitivity: Fluphenazine Decanoate oily Injection is contraindicated in patients with hypersensitivity to the drug.
- Depressed States: Contraindicated in comatose or severely depressed states.
- Blood Dyscrasias: Contraindicated in the presence of blood dyscrasias.
- Liver Disease: Contraindicated in patients with liver disease.
- Pregnancy (3rd Trimester): Contraindicated in the third trimester of pregnancy.
- Lactation: Contraindicated during lactation.
✔️ Pregnancy & Lactation
The safety for the use of Fluphenazine decanoate during pregnancy has not yet been established; therefore the possible hazards should be weighed against the potential benefits when administering this drug to pregnant patients.
✔️ Precautions & Warnings
- Special precautions in convulsive disorders, hepatic, renal, cerebrovascular, respiratory, and cardiovascular diseases.
- Precaution in phenochromocytoma, bone marrow suppression, elderly or debilitated patients.
- Lactation: Drug enters breast milk; not recommended.
✔️ Storage Conditions
- Keep Fenazine Injection out of reach in children
- Store at a temperature not exceeding 20°C-25°C, away from light
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